منابع مشابه
Glucocorticoids and foetal heart maturation; implications for prematurity and foetal programming.
Glucocorticoids are steroid hormones, essential in mammals to prepare for life after birth. Blood levels of glucocorticoids (cortisol in most mammals including humans; corticosterone in rats and mice) rise dramatically shortly before birth. This is mimicked clinically in the routine administration of synthetic glucocorticoids to pregnant women threatened by a preterm birth or to preterm infants...
متن کاملFoetal scanning
enlargement andreduced corticalvolume arecorrelatesofchronic schizophrenia.We investigatedwhether genetic risk for psychosis is related to differences in foetal brain development asmeasuredby prenatalultrasonography.Routine foetal cerebralmeasures at19^23 weeks of gestationwere comparedbetweenthe offspring of 35 womenwith a historyof psychosis and105 controlwomenmatched for gestational age.Over...
متن کاملRole of foetal programming and epigenetic mechanisms in the pathogenesis of arterial hypertension
Essential hypertension remains poorly understood, despite the enormous efforts of research, which brought understanding of certain physiopathological and treat ment mechanisms. New insights have emerged from recent data showing that environmental insults during (in vitro) fertilisation, foetal, perinatal and childhood periods may lead to vascular dysfunction and hyper tension later in life (t...
متن کاملFoetal programming by methyl donor deficiency produces steato-hepatitis in rats exposed to high fat diet
Non-alcoholic steatohepatitis (NASH) is a manifestation of metabolic syndrome, which emerges as a major public health problem. Deficiency in methyl donors (folate and vitamin B12) during gestation and lactation is frequent in humans and produces foetal programming effects of metabolic syndrome, with small birth weight and liver steatosis at day 21 (d21), in rat pups. We investigated the effects...
متن کاملOffspring Hormones Reflect the Maternal Prenatal Social Environment: Potential for Foetal Programming?
Females of many species adaptively program their offspring to predictable environmental conditions, a process that is often mediated by hormones. Laboratory studies have shown, for instance, that social density affects levels of maternal cortisol and testosterone, leading to fitness-relevant changes in offspring physiology and behaviour. However, the effects of social density remain poorly unde...
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ژورنال
عنوان ژورنال: Acta Physiologica
سال: 2019
ISSN: 1748-1708,1748-1716
DOI: 10.1111/apha.13403